genetic mutation

noun

plural genetic mutations
: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes
Lacking working copies of the p53 gene, cells can begin to divide without check, though several other genetic mutations are thought to be needed to foster a full-blown malignancy.—Natalie Angier

Examples of genetic mutation in a Sentence

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Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
But now, the new study reveals how many of these diverse genetic mutations physically connect and rewire protein interactions in the developing brain, driving the emergence of autism. — Jacqueline Howard, CNN Money, 27 Aug. 2026 While cognitive decline is far more common among individuals over 65 years, some genetic mutations cause the same characteristic loss of memory and mental processing in children. — Mike McRae 26, New Atlas, 26 Aug. 2026 The robust gains and lack of safety concerns led the Food and Drug Administration to approve Regeneron’s Otarmeni therapy in April for the small group of people with this rare genetic mutation. — O. Rose Broderick, STAT, 11 Aug. 2026 Within short spine syndrome, Ekenstedt said there are about five or six different underlying genetic mutations. — Greta Cross, USA Today, 31 July 2026 See All Example Sentences for genetic mutation

Word History

First Known Use

1915, in the meaning defined above

Time Traveler
The first known use of genetic mutation was in 1915

Rhymes for genetic mutation

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Browse Nearby Words

genetic modification
genetic mutation
genetics
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Cite this Entry

“Genetic mutation.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/genetic%20mutation. Accessed 1 Sep. 2026.

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Medical Definition

genetic mutation

noun
: a permanent alteration in the nucleotide sequence of one or more genes or in the number or structure of one or more chromosomes
Gaucher's disease results from one of many genetic mutations that can either slow or prevent the breakdown of certain glycolipids, which accumulate in storage vesicles and eventually kill cells.—Joseph Alper
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